Molecular Epidemiology of Multidrug-resistant Escherichia coli from Urinary Tract Infections

Objectives: The purpose of this study was to investigate the phylogenetic groups, antibiotic resistance, resistance genes (ARGs), integrons, extraintestinal virulence and genetic diversity Escherichia coli isolates from human urinary tract infection. Methods: A total 100 E. were collected patients with infections in Kerala, South India. Antibiotic susceptibility testing all against different antibiotics determined by disc diffusion method. Phylogenetic genes, ARGs, integrons detected PCR. Enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) used check relatedness among isolates. Results: have mainly belonged group B2. Resistance ampicillin most frequent followed cefoxitin, cefpodoxime, nalidixic acid, trimethoprim, co-trimoxazole. Among isolates, 96% multidrug-resistant (MDR), 86% 32% harbored ARGs integrase 1 (int1) respectively. Seventy-nine percent pathogenic (ExPEC), them (n = 68) ARGs. One extensively drug-resistant (XDR) ExPEC obtained study. present revealed a significant association between presence resistance. high degree observed ARGs-harboring Conclusion: Understanding would result proper treatment infections. J Microbiol Infect Dis 2021; 11(2):66-73.